Link between aging and the nucleolus
نویسندگان
چکیده
منابع مشابه
A New Link Between Senescence and Aging
Cellular senescence is a distinctive form of cell cycle arrest that has been suggested to modulate the processes of tumor suppression and aging. Though a detailed understanding of the cellular machinery regulating this process is emerging, a more thorough understanding of the key players linking senescence to organismal aging is needed. The recent discovery that loss of the p53-related protein ...
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Nopp140 Functions as a Molecular Link Between the Nucleolus and the Coiled Bodies
Coiled bodies are small nuclear organelles that are highly enriched in small nuclear RNAs, and that have long been thought to be associated with the nucleolus. Here we use mutational analysis, transient transfections, and the yeast two-hybrid system to show that the nucleolar phosphoprotein Nopp140 functions as a molecular link between the two prominent nuclear organelles. Exogenous Nopp140 acc...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1997
ISSN: 0890-9369
DOI: 10.1101/gad.11.19.2449